B4163 - Longitudinal Blood Pressure GWAS - 18/10/2022
B number:
B4163
Principal applicant name:
Kari E. North | University of North Carolina Chapel Hill (USA)
Co-applicants:
Dr. Samson Okello, Assist. Prof. Heather Highland, Misa Graff
Title of project:
Longitudinal Blood Pressure GWAS
Proposal summary:
Blood pressure increases with aging and individuals with elevated blood pressure during adolescence and early adulthood are more likely to have hypertension and heart disease later in life. Knowledge of genetic factors associated with blood pressure during adolescence and early adulthood may help in the development of strategies to control blood pressure and prevent heart disease.
Impact of research:
We anticipate insights into mechanistic pathways leading to hypertension, identifying novel targets for early prevention and pharmaceutical intervention to reduce CVD-related morbidity. By addressing BP in a life course approach, our work will contribute to the understanding of CVD risk in early life.
Date proposal received:
Friday, 14 October, 2022
Date proposal approved:
Tuesday, 18 October, 2022
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Hypertension, GWAS, Blood pressure