B4159 - Genome-wide association study GWAS of blood pressure in adults - 11/10/2022

B number: 
B4159
Principal applicant name: 
Qian Yang | University of Bristol
Co-applicants: 
Prof Deborah A Lawlor, Prof Nicholas J Timpson
Title of project: 
Genome-wide association study (GWAS) of blood pressure in adults
Proposal summary: 

The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium invites ALSPAC and Bristol researchers to take part in a large GWAS of blood pressure traits, which include systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP, i.e. SBP-DBP). The main aims of CHARGE's GWAS are to (1) identify novel loci for BP traits separately by sex; (2) identify gene-sleep interaction effects on BP traits by sex. These analyses will follow the most recent analysis plan (currently 'Phase II analysis plan for sleep and blood pressure' version 4.3) provided by CHARGE. Only summary statistics will be shared with CHARGE. Based on the final GWAS results, subsequent analyses (e.g. Mendelian randomization) would be conducted by CHARGE based on the summary statistics.

Impact of research: 
This study will help identify novel genetic variants involved in BP traits and genetic variants affect these traits taking into account potential interaction with a lifestyle factor.
Date proposal received: 
Monday, 3 October, 2022
Date proposal approved: 
Tuesday, 11 October, 2022
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Hypertension, GWAS, Blood pressure