B4157 - Associations between polygenic risk scores reaction time variability and ADHD-traits during adolescence - 11/10/2022

B number: 
B4157
Principal applicant name: 
Christian Krog Tamnes | University of Oslo
Co-applicants: 
Ingrid Anna Ørstavik Dissen, Rosa Catherine Gillespie Cheesman, Dr., Alexandra Havdahl, Dr., Iroise Dumontheil, Dr.
Title of project: 
Associations between polygenic risk scores, reaction time variability and ADHD-traits during adolescence
Proposal summary: 

The current project is a student project that is linked to the already approved project: B3840 Developmental pathways to mental health problems. All needed data are available through B3840.

Attention deficit/hyperactivity-disorder (ADHD) is a highly heritable and heterogenous neurodevelopmental disorder associated with a range of cognitive deficits and functional outcomes. The complex pathways in which genetic risk gives rise to traits associated with ADHD remains to be specified. One cognitive phenotype associated with ADHD is Intraindividual Variability (IIV), usually measured as Reaction Time Variability (RTV). How RTV relates to behavioural symptoms of ADHD, and whether it constitutes a specific marker of ADHD or represents a marker of psychopathology in general, is currently debated. A deeper understanding of how genetic risk for ADHD relates to RTV and how RTV in turn relates to ADHD symptoms may have implications for understanding the links between genetic risk, cognition, and behavioural manifestations of ADHD.

Impact of research: 
Date proposal received: 
Friday, 30 September, 2022
Date proposal approved: 
Tuesday, 11 October, 2022
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, ADHD, Polygenic scores Behavioural task, Cognition - cognitive function