B4154 - The role of genetics in food allergy - 03/10/2022
B number:
B4154
Principal applicant name:
Annette Peters | Helmholtz Munich and Ludwig Maximilian University of Munich (Germany)
Co-applicants:
Lisa Maier
Title of project:
The role of genetics in food allergy
Proposal summary:
The prevalence of food allergies has steadily increased in recent decades. This highlights the contribution of environmental and lifestyle factors, which act on the background of individual genetic susceptibility to shape the responsiveness of the immune system to allergenic triggers. A few genetic regions associated with food allergy have been identified but the number of genome-wide association studies (GWAS) on food allergy to date is limited and often restricted to one specific food allergen. Therefore, we aim to conduct a large-scale meta-analysis of GWAS on food allergies.
Impact of research:
This project aims in particular to identify new risk loci for food allergy, as only a few genes have been identified so far in studies with small sample sizes. Conducting a GWAS meta-analysis on food allergy will expand and improve the understanding of genetic mechanisms of food allergies, which is an essential prerequisite for developing hypothesis-generating approaches to food allergy prevention and therapy.
Date proposal received:
Thursday, 22 September, 2022
Date proposal approved:
Monday, 3 October, 2022
Keywords:
Genetics, Allergy, GWAS, Statistical methods, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Cohort studies - attrition, bias, participant engagement, ethics, Genetic epidemiology, Genetics, Genome wide association study, Immunity, Statistical methods