B4150 - A Network Approach to Understanding Co-Occurring Mental Health Conditions in People with Autism and High Autistic Traits - 03/10/2022

B number: 
B4150
Principal applicant name: 
Matthew Hollocks | King's College London
Co-applicants: 
Dr Anat Zaidman-Zait, Prof Will Mandy
Title of project: 
A Network Approach to Understanding Co-Occurring Mental Health Conditions in People with Autism and High Autistic Traits
Proposal summary: 

Autism spectrum disorder is a neurodevelopmental condition characterised by difficulties with reciprocal social communication, restricted interests, repetitive behaviours, and sensory difficulties. In addition to these core features autistic people are at extremely high risk of developing additional mental health difficulties. For example, between 40% to 78% of children with autism have at least one anxiety disorder, almost four times the rate observed in children without the diagnosis. In addition, rates of depression and ADHD are extremely high. Adding to this complex picture is the fact that an autistic person will often experience more than one of these additional diagnoses. Current statistical approaches to the study of the co-occurrence of mental health conditions in autism fail to consider of important associations at a symptom level both within and between conditions, potentially preventing vital insights into key problem areas which could be targeted by interventions. To address this, we plan to apply an alternative and novel approach (Network analysis) to understanding the underlying structure of co-occurring conditions in this highly complex and heterogeneous population.

Impact of research: 
The main outcome of this research will be a novel understanding of the nature of co-occurring mental health conditions in autism. Our approach will allow us to identify key symptoms or clusters of symptoms which will guide future research on the assessment, prevention and treatment of the mental health difficulties experienced by autistic people.
Date proposal received: 
Wednesday, 28 September, 2022
Date proposal approved: 
Monday, 3 October, 2022
Keywords: 
Mental health - Psychology, Psychiatry, Cognition, Mental health, Statistical methods, Childhood - childcare, childhood adversity, Development, Psychology - personality, Statistical methods