B4113 - Exploring the epigenetic profiles of vapers smokers dual users abstainers and never users in ALSPAC - 20/09/2022
B number:
B4113
Principal applicant name:
Jasmine Khouja | University of Bristol (United Kingdom)
Co-applicants:
Dr Rebecca Richmond, Prof Marcus Munafo, Dr Matthew Suderman, Dr Ryan Langdon, Alex Andrayas
Title of project:
Exploring the epigenetic profiles of vapers, smokers, dual users, abstainers and never users in ALSPAC
Proposal summary:
DNA methylation is an epigenetic change that can influence how our genes are expressed. Smoking has been found to influence DNA methylation, and these changes could be responsible for some of the negative health consequences of smoking. In comparison, the epigenetic changes associated with e-cigarette use are not well known. In this project, we will explore how e-cigarette use is associated with DNA methylation.
Impact of research:
1. Publications and/or conference presentations that will further understanding of the epigenetic changes associated with e-cigarette use.
2. Findings for inclusion in future grant applications and possible publications.
Date proposal received:
Wednesday, 20 July, 2022
Date proposal approved:
Tuesday, 26 July, 2022
Keywords:
Molecular genetics and genomics, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Computer simulations/modelling/algorithms, Statistical methods, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., BMI, Epigenetics, Genetic epidemiology