B4121 - Mechanisms linking the natriuretic peptide receptor-C gene to elevated blood pressure Genetic epidemiology study - 01/08/2022
B number:
B4121
Principal applicant name:
Zoe Adams | School of Physiology, Pharmacology & Neuroscience, University of Bristol (United Kingdom)
Co-applicants:
Dr Carolina Borges, Dr Alba Fernandez-Sanles, Dr Emma Hart
Title of project:
Mechanisms linking the natriuretic peptide receptor-C gene to elevated blood pressure: Genetic epidemiology study.
Proposal summary:
Previous research has identified several regions of the human genome associated with high blood pressure. One such region is the NPR3 gene, encoding the natriuretic peptide receptor-C. Whilst genetic variants in this region are associated with high blood pressure, it is not known which variant/s drive the association or whether the effect on blood pressure occurs through altered expression of the NPR3 gene. This study will use existing ALSPAC data to investigate the association between the NPR3 gene and high blood pressure.
Impact of research:
This study will provide insights into the mechanism underlying the association between the NPR3 gene and elevated blood pressure, with the ultimate goal of determining whether the NPR3 gene is a potential target for treatment of hypertension. The outcomes of this study will inform a related physiological study which aims to assess the effect of NPR3 genotype on regulation of blood pressure and vascular tone (a separate future ALSPAC proposal).
Date proposal received:
Monday, 1 August, 2022
Date proposal approved:
Monday, 1 August, 2022
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Hypertension, GWAS, Statistical methods, Cardiovascular, Genetic epidemiology, Mendelian randomisation