B4047 - Assessing the association between a DNA methylation-based exposure score for maternal smoking during pregnancy and neurodevelopm - 14/06/2022
B number:
B4047
Principal applicant name:
Rachelle Pretorius | Telethonkids Institute (Western Australia )
Co-applicants:
Prof Rae-Chi Huang
Title of project:
Assessing the association between a DNA methylation-based exposure score for maternal smoking during pregnancy and neurodevelopm
Proposal summary:
Maternal smoking during pregnancy has been related to lower child neurodevelopment and higher behavioural problems. However, there is a need to replicate such analyses in a consortium of several European cohorts, using machine learning-based DNA methylation smoking scores. The harmonization of mental health problems in several population-based birth cohorts will allow us to perform trajectory analyses with specific mental health domains.
Impact of research:
Using the extensive data available form a large number of mother-children pair will assist in
our understanding of the role of maternal smoking on DNA methylation and childhood mental
health outcomes. Findings from the studies will directly impact implementation
activities and improve health outcomes of future generations
Date proposal received:
Thursday, 7 April, 2022
Date proposal approved:
Tuesday, 14 June, 2022
Keywords:
Mental health - Psychology, Psychiatry, Cognition, Cognitive impairment, Statistical methods, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Genetics, Intelligence - memory, Mothers - maternal age, menopause, obstetrics, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Offspring, Psychology - personality, Statistical methods, Birth outcomes, Cohort studies - attrition, bias, participant engagement, ethics, Cognition - cognitive function, Communication (including non-verbal), Development, Environment - enviromental exposure, pollution, Epigenetics, Genetic epidemiology