B4082 - Sex stratified acne GWAS meta-analysis - 27/05/2022

B number: 
Principal applicant name: 
Josine Min | MRC IEU, University of Bristol (United Kingdom)
Dr. Jake Saklatvala, Professor Michael Simpson, Professor Catherine Smith
Title of project: 
Sex stratified acne GWAS meta-analysis
Proposal summary: 

Acne vulgaris (acne) is a common inflammatory disorder of the cutaneous pilo-sebaceous unit. Family and twin studies indicate a substantial genetic contribution to acne susceptibility with heritability estimates of 78 and 81%. Genome-wide association studies (GWAS) have made a substantial contribution to the understanding of the genetic basis of several common cutaneous inflammatory disorders. Here we perform a genomewide association analysis, comparing severe cases of acne with controls in females and males separately to identify and replicate genetic determinants.

Impact of research: 
Date proposal received: 
Friday, 27 May, 2022
Date proposal approved: 
Friday, 27 May, 2022
Genetic epidemiology (including association studies and mendelian randomisation), Skin diseases - acne vulgaris, GWAS, Dermatology