B4064 - Associations of diabetic traits blood pressure general and central adiposity with COVID-19 and long COVID a prospective study - 20/05/2022

B number: 
Principal applicant name: 
Nic Timpson | MRC-IEU
Fergus Hamilton
Title of project: 
Associations of diabetic traits, blood pressure, general and central adiposity with COVID-19 and long COVID: a prospective study
Proposal summary: 

COVID-19 patients with high BMI and waist to hip ratio (WHR), diabetes and hypertension showed a higher risk of dying and severe disease in the early pandemic (1-3), but the role in susceptibility for COVID-19 and long COVID and the extent to which associations are due to confounding is still mostly unclear (4-7). Previous analysis on infection and long Covid risk mainly used binary measures of obesity or overweight, known diabetes status and hypertension, which could introduce measurement error, reduce statistical power, and does not allow to disentangle whether an association is related to treatment or due to the disease itself. Using pre-pandemic diabetes, measured blood glucose and HbA1c, BMI, WHR, body fat and blood pressure could improve measurement quality by identifying disease control, severity, and those with prediabetes.

Impact of research: 
Help understand impact of BMI, weight, height, and other linked variables on long covid.
Date proposal received: 
Tuesday, 17 May, 2022
Date proposal approved: 
Friday, 20 May, 2022
Immunology, Infection, GWAS, Biological samples -e.g. blood, cell lines, saliva, etc.