B4051 - Early-life exposure to indoor mould and lung function trajectories in ALSPAC - 20/04/2022

B number: 
Principal applicant name: 
Raquel Granell | MRC Integrative Epidemiology Unit (MRC-IEU) Bristol Medical School (Population Health Sciences)
Mr Joshua Khan, Dr James Dodd, Dr Chin Yang Shapland.
Title of project: 
Early-life exposure to indoor mould and lung function trajectories in ALSPAC
Proposal summary: 

Indoor mould is known to damage respiratory health, including worsening exacerbations and increasing occurrence of asthma. This is a prevalent issue and the number of people exposed to indoor mould exposure has been increasing (from 18% to 50%). This exposure is at risk of increasing with further climate change,for example with increasing numbers of floods occurring there will be a worsening of indoor mould growth. Previous studies have shown that early-life exposure to risk factors, such as air pollution, are associated with reduced lung growth and lower FEV1 as well as detrimental lung function trajectories; some of these trajectories are characterised by earlier onset respiratory disease and associated with premature death. This study will investigate the early life influence of indoor mould on lung function trajectories up to 24 years old (i.e. nearing respiratory physiological plateau) using data from the ALSPAC population based birth cohort.

Impact of research: 
This work will be the basis for Josh's MSc dissertation, and hopefully will be able to get a publication.
Date proposal received: 
Wednesday, 13 April, 2022
Date proposal approved: 
Wednesday, 20 April, 2022
Epidemiology, Respiratory- lung function, Statistical methods, Environment - enviromental exposure, pollution