B3787 - The effect of timing and cessation of maternal smoking upon the DNA methylation score - 14/02/2022
B number:
B3787
Principal applicant name:
Rae-Chi Huang | Lifecycle (Australia)
Co-applicants:
Jennie Carson, Dr Phil Melton, Dr Sylvain Sebert, Kimberley Burrows
Title of project:
The effect of timing and cessation of maternal smoking upon the DNA methylation score
Proposal summary:
The smoking score was developed in the Raine Study (partner: University of Western Australia/Telethon Kids Institute, Perth, Western Australia) and the Northern Finland Birth Cohorts 1986 and 1966 (partner: University of Oulu, Oulu, Finland). For the score development, DNA methylation data measured with the Illumina HumanMethylation450 BeadChip array was utilized, together with a binary variable, indicating if the study participant’s mother was smoking during pregnancy.
Our hypothesis is that the smoking score captures and quantifies latent information on early life exposure. We also hypothesize that it quantifies the persistent changes that occur systemically in the offspring with maternal smoking exposure in utero.
Impact of research:
The intention of this research is to identify which trimester of smoking during pregnancy has the greatest impact on the child's smoking score.
Date proposal received:
Monday, 31 January, 2022
Date proposal approved:
Monday, 14 February, 2022
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Statistical methods, Epigenetics