B3978 - Genome-wide association study of bone mineral density in ALSPAC children and mothers - 04/02/2022

B number: 
B3978
Principal applicant name: 
Monika Frysz | University of Bristol (United Kingdom)
Co-applicants: 
Prof Jon Tobias, Dr Ahmed Elhakeem, John Kemp
Title of project: 
Genome-wide association study of bone mineral density in ALSPAC children and mothers
Proposal summary: 

Osteoporosis is a common age-related condition with a strong genetic component. Osteoporotic fractures significantly contribute to disease burden and costs. Whilst a number of genes responsible have been identified, many gene variants each contribute to the disease but each with subtle effect.
Previous GEnetic Factors for OSteoporosis Consortium (GEFOS) study identified a number of BMD-related loci using a genome-wide association study (GWAS). As part of this collaboration, an ongoing meta-analysis of four DXA-derived BMD traits is being conducted. Cohorts previously involved as well as new and updated cohorts are being invited to take part in this effort.

Impact of research: 
Publication in a high impact journal
Date proposal received: 
Friday, 21 January, 2022
Date proposal approved: 
Friday, 4 February, 2022
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Bone disorders - arthritis, osteoporosis, GWAS, Genome wide association study