B3946 - Maternal diabetes in pregnancy and developmental programming of neurodevelopment disorders An inflammatory Hypothesis - 24/01/2022

B number: 
Principal applicant name: 
Rachelle Pretorius | Telethonkids Institute (Western Australia )
Prof Rae-Chi Huang
Title of project: 
Maternal diabetes in pregnancy and developmental programming of neurodevelopment disorders: An inflammatory Hypothesis
Proposal summary: 

Cognitive and behavioral disorders among children are on the increase. Exposures to metabolic disorders during pregnancy may influence the offspring’s psychopathology and neurodevelopment. This project will assess the relationship between diabetes before and during pregnancy on various aspects of child cognitive and behavioral development

Impact of research: 
Using the extensive data available form a large number of mother-children pair will assist in our understanding of the role of maternal metabolic health and childhood mental health outcomes. Findings from the studies will directly impact implementation activities and improve health outcomes of future generations
Date proposal received: 
Tuesday, 7 December, 2021
Date proposal approved: 
Monday, 20 December, 2021
Mental health - Psychology, Psychiatry, Cognition, Cognitive impairment, Congenital abnormalities, Diabetes, Learning difficulty, Mental health, Obesity, Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., Statistical methods, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Birth outcomes, Intelligence - memory, Mothers - maternal age, menopause, obstetrics, Metabolic - metabolism, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Nutrition - breast feeding, diet, Offspring, Psychology - personality, Speech and language, Statistical methods, Blood pressure, BMI, Cohort studies - attrition, bias, participant engagement, ethics, Childhood - childcare, childhood adversity, Cognition - cognitive function, Development, Endocrine - endocrine disrupters, Environment - enviromental exposure, pollution