B3969 - Contributions of fat and lean mass to blood pressure phenotypes in the young - 17/01/2022

B number: 
B3969
Principal applicant name: 
Scott Chiesa | UCL (United Kingdom)
Co-applicants: 
Valerie Mok
Title of project: 
Contributions of fat and lean mass to blood pressure phenotypes in the young
Proposal summary: 

Using a recall-by-genotype design, we have recently shown increases in BMI to be causally related to elevations in systolic - and to a lesser extent - diastolic blood pressure. While these changes are often attributed to the effects of excess adiposity, increases in BMI are known to arise from increases in both fat and underlying lean tissue, both of which may drive changes in blood pressure. This student project aims to investigate the extent to which these differing tissue types may contribute to changes in blood pressure commonly observed in the young.

Impact of research: 
Conferences presentations and combination with other analyses to generate paper in high-impact journal.
Date proposal received: 
Thursday, 6 January, 2022
Date proposal approved: 
Monday, 17 January, 2022
Keywords: 
Epidemiology, Hypertension, Obesity, population study, Blood pressure, BMI, Cardiovascular