B3940 - The DASH-style dietary pattern in childhood in relation to Cardiometabolic Risk in early adulthood in the ALSPAC cohort - 10/12/2021

B number: 
Principal applicant name: 
Genevieve Buckland | Bristol Medical, Centre for Academic Child Health (United Kingdom)
Dr. Caroline Taylor, Dr. Pauline Emmett
Title of project: 
The DASH-style dietary pattern in childhood in relation to Cardiometabolic Risk in early adulthood in the ALSPAC cohort.
Proposal summary: 

The Dietary Approaches to Stop Hypertension (DASH) diet is considered a healthy dietary pattern that is associated with lower blood pressure, reduced risk of cardiovascular diseases, type 2 diabetes and related cardiometabolic risk factors in adults. However, research into the cardiometabolic benefits of this dietary pattern during childhood and adolescence is scarce, especially from large studies following-up children into adulthood.
We plan to use dietary data collected in ALSPAC when the children were 7 years, 10 years and 13 years old to assess how closely their diets aligned to a DASH-style dietary pattern. Apart from being low in salt, this dietary patter is high in fruits and vegetables, nuts and pulses, wholegrains, and low-fat dairy products and low in red and processed meat, sweetened drinks and saturated fat. We will explore whether the children with more DASH-style dietary patterns during childhood have better overall cardiometabolic health when they are 17 years and 24 years old, and if so which aspects of cardiometabolic health are benefited most. Overall cardiometabolic health will be measured using a Cardiometabolic Risk (CMR) score that takes into account each participants’ glucose, insulin, triglyceride and cholesterol levels, blood pressure and body composition.

Impact of research: 
This study will advance our understanding of the dietary determinants during childhood for the development of cardiometabolic risk factors in early adulthood. Research in this area from large prospective studies with long follow-up times are limited. Dietary habits are still evolving during childhood and adolescence and by studying dietary patterns at three time points we will also be able to assess if there are critical time point(s) when these dietary habits are more important for future cardiometabolic health. We expect our findings to contribute to the scientific evidence needed to develop effective preventative strategies and identify and manage at risk groups, where there is a particular shortfall in clinical and public health practice. For instance, the results could help when designing specific dietary interventions targeted at high-risk children and adolescents to reduce their risk of developing cardiometabolic diseases later in adulthood.
Date proposal received: 
Monday, 29 November, 2021
Date proposal approved: 
Friday, 10 December, 2021
Epidemiology, Hypertension, Association analysis (using regression models) of dietary and cardiometabolic data. , Nutrition - breast feeding, diet