B3863 - How the interaction of genetic and environmental factors influences human traits - 23/11/2021

B number: 
B3863
Principal applicant name: 
Tomas Fitzgerald | EMBL-EBI (United Kingdom)
Co-applicants: 
Ewan Birney , Panagiotis Sergouniotis
Title of project: 
How the interaction of genetic and environmental factors influences human traits
Proposal summary: 

Subtle differences in a person's genes can affect their susceptibility to disease and cause them to respond differently an environmental exposure compared to other people. Interestingly, some people may develop a disease after being exposed to specific genetic and enviromental factors while others may not.

This project will combine genetic and environmental information from thousands of people aiming to understand how these factors influence risk to disease and characteristics like immune system response and vision.

As we learn more about the connection between genes and the environment, we can pursue new approaches for preventing and treating disease.

Impact of research: 
We expect our study to create resources for gene-environment interaction analyses. We also hope to develop tools that more systematically identify participation bias and correct its effect on genetic association results.
Date proposal received: 
Monday, 18 October, 2021
Date proposal approved: 
Tuesday, 23 November, 2021
Keywords: 
Bioinformatics, Neuro development , GWAS, Vision