B3910 - Genetic determinants of distinct body mass index trajectories to young-adulthood obesity - 25/10/2021
B number:
B3910
Principal applicant name:
Laura Howe | MRC Integrative Epidemiology Unit at the University of Bristol (United Kingdom)
Co-applicants:
Stephanie Page, Amanda Hughes, William Johnson, Thomas Norris
Title of project:
Genetic determinants of distinct body mass index trajectories to young-adulthood obesity
Proposal summary:
Different body mass index (BMI) trajectories that result in obesity may have diverse aetiologies and health consequences, yet this heterogeneity is poorly understood. Previous research in the ALSPAC cohort has identified patterns of BMI development between ages 7 and 24 (Norris et al). Analyses using these patterns showed that people who have high and stable BMI across childhood may have lower cardiometabolic disease risk than individuals who do not become overweight or obese until late adolescence. How genetic factors relate to these patterns of BMI development is not known.
Impact of research:
aetiological understanding of BMI trajectories
Date proposal received:
Friday, 15 October, 2021
Date proposal approved:
Monday, 25 October, 2021
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Obesity, Genetic epidemiology, Growth