B3872 - Genome wide association study of progression from impaired fasting glucose to type 2 diabetes - 20/09/2021

B number: 
B3872
Principal applicant name: 
April Hartley | Integrative Epidemiology Unit (UK)
Co-applicants: 
Professor Kate Tilling, Professor George Davey Smith, Dr Venexia Walker
Title of project: 
Genome wide association study of progression from impaired fasting glucose to type 2 diabetes
Proposal summary: 

Pre-diabetes is a condition where blood glucose levels are elevated above normal, but below the threshold to be defined as type 2 diabetes. It is estimated that 70% of those meeting the criteria for pre-diabetes will eventually progress to type 2 diabetes, which is a chronic, incurable condition associated with various other comorbidities. It is therefore important to understand why some individuals progress from pre-diabetes to type 2 diabetes, so that we can develop interventions to stop this happening. We therefore aim to identify the genetic basis for why some individuals progress from pre-diabetes to type 2 diabetes.

Impact of research: 
The ALSPAC data will contribute to a larger GWAS meta-analysis which will hopefully identify genes involved in progression from pre-diabetes to type 2 diabetes. The resulting summary statistics will also be used for two-sample Mendelian randomization analyses to identify non-genetic risk factors. Identifying risk factors for progression from pre-diabetes to diabetes may aid the development of interventions to prevent diabetes onset in those at high risk.
Date proposal received: 
Tuesday, 7 September, 2021
Date proposal approved: 
Monday, 20 September, 2021
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), Diabetes, GWAS, Statistical methods, Biological samples -e.g. blood, cell lines, saliva, etc., Genetic epidemiology, Genetics, Genomics, Genome wide association study, Mendelian randomisation, Metabolic - metabolism, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Statistical methods