B3844 - MR-PREG Consortium 26-07-2021 - 103144 - 20/09/2021

B number: 
Principal applicant name: 
Amy Taylor | University of Bristol (United Kingdom)
Carolina Borges, Deborah Lawlor, Alice Carter, Marwa Al Arab, Nancy Mcbride, Ana Luiza Soares, Qian Yang, Alba Fernandez-Sanles, Fanny Kilpi
Title of project: 
MR-PREG Consortium (26-07-2021 - 10:31:44)
Proposal summary: 

ALSPAC contributes to a group of studies called MR-PREG which aims to investigate the impact of maternal exposures during pregnancy (such as BMI, smoking, blood pressure) on pregnancy complications, perinatal outcomes and later offspring outcomes. MR-PREG uses genetic data to explore whether associations between maternal exposures and these outcomes are likely to be causal.

Impact of research: 
There are already several papers in progress from the initial MR-PREG analyses. This work will be important for identifying the impact of maternal exposures during pregnancy and possible targets for intervention (e.g. healthy BMI ranges for pregnant women to prevent preterm birth).
Date proposal received: 
Monday, 6 September, 2021
Date proposal approved: 
Monday, 20 September, 2021
Genetic epidemiology (including association studies and mendelian randomisation), Pregnancy - e.g. reproductive health, postnatal depression, birth outcomes, etc., GWAS, Mothers - maternal age, menopause, obstetrics