B3864 - Variable antibody response to SARS-CoV-2 and the effects of vaccination career - 02/09/2021
B number:
B3864
Principal applicant name:
Richard Stanton | University of Cardiff (UK)
Co-applicants:
Prof Nic Timpson, Ass Prof Kate Northstons, Dr Sue Ring
Title of project:
Variable antibody response to SARS-CoV-2 and the effects of vaccination career.
Proposal summary:
This project sets out to use existing samples (on N=4 participants) collected as part of the UKCiC initiative to examine the ability of SARS-CoV-2 vaccination to recover variable immunological response to wild infection. Data on continuously assessed antibody response to wild infection will be used to identify those with low response and then biological samples available over a schedule of first and second vaccinations will be used to examine the impact of these interventions.
Impact of research:
Our underlying hypothesis is that the type of humoral response generated from natural infection is superior to vaccination, in terms of the ability of non-neutralising antibodies to activate cellular immunity. If this is true, and we can establish why it occurs, it may provide a means to enhance the efficacy of vaccine-induced responses.
Date proposal received:
Wednesday, 1 September, 2021
Date proposal approved:
Wednesday, 1 September, 2021
Keywords:
Immunology, Infection, Biological sample analysis of immunological response to SARS-CoV-2, Immunity