B3819 - Pair-wise conditional and colocalization analysis -- an application to MS - 29/07/2021
B number:
B3819
Principal applicant name:
Jie Zheng | University Of Bristol (United Kingdom)
Co-applicants:
Dr Jamie Robinson, Professor Tom Gaunt
Title of project:
Pair-wise conditional and colocalization analysis -- an application to MS
Proposal summary:
Genetic colocalization is a genetic epidemiology method that have been widely applied to understand the role of molecular traits on human diseases. However, the method has the assumption that there is only one association signal exist in the test region, which is not always the case.
In this project, we aim to refine the method by integrating conditional analysis approach (GCTA-COJO) with colocalization approach. We will develop the method using C++ and apply it to a wide range of molecular traits and disease outcomes. The ALSPAC genotype data will be used as the reference panel for the application of the novel method.
Impact of research:
PWCoCo, the new method we plan to develop, will be a leading method that change the gameset of genetic colocalization approach.
The application of PWCoCo will bring causal links between genes and diseases, which some of the genes could be drug targets for novel drugs.
Date proposal received:
Tuesday, 22 June, 2021
Date proposal approved:
Thursday, 8 July, 2021
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Allergy, GWAS, Genetic epidemiology