B3814 - Polygenic susceptibility in chronic air pollution exposure associated adverse respiratory health in adolescents a meta-analysis - 05/07/2021
B number:
B3814
Principal applicant name:
Raquel Granell | MRC Integrative Epidemiology Unit
Co-applicants:
Dr Tamara Schikowski, Sara Kress, Dr Claudia Wigmann
Title of project:
Polygenic susceptibility in chronic air pollution exposure associated adverse respiratory health in adolescents: a meta-analysis
Proposal summary:
Several studies support an association between being exposed to air pollution and having respiratory health problems in adolescence. However, only some of those who are highly exposed to air pollution develop respiratory diseases. Genetics play a role in how an individual respons to air pollution exposure as well as in the probability to develop air pollution induced respiratory health problems. We want to investigate if there is a difference in how air pollution affects our respiratory health, when comparing 'genetic low-risk' and 'genetic high-risk' groups of people.
Impact of research:
Date proposal received:
Thursday, 17 June, 2021
Date proposal approved:
Monday, 21 June, 2021
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation)