B3792 - Socioeconomic position SEP influence on the early-life individual exposome - 03/06/2021

B number: 
Principal applicant name: 
Costanza Pizzi | University of Turin
Title of project: 
Socioeconomic position (SEP) influence on the early-life individual exposome
Proposal summary: 

This project will study how the child SEP at birth drives the personal exposome during infancy (0-2 years), accounting for geographical variability among cities and countries. The SEP will be measured using the EHII (Equivalized Household Income Indicator) developed within task 3.1.1 and maternal education. The exposures considered for this analysis include the urban environment exposures created within task 3.1.3, the diet exposures created within task 3.1.4, breastfeeding, passive smoking and exposure to pets.
We will study the SEP-exposome relationship using two main different approaches: i) we will fit standard regression models to evaluate the effect of SEP on each exposure accounting for multiple comparisons (Exposome Wide Association Study - ExWAS approach, but with the exposures as the dependent variables); ii) we will perform city-specific principal component analysis to reduce the exposome dimension and derive summary exposure indicators (the first principal components) and then fit standard regression models to evaluate the association between SEP and these summary indicators. We will conduct cohort/cities-specific analysis to take into account the fact that the role of SEP likely varies among cities and countries and considering maternal age, parity and ethnicity as potential confounders.

Impact of research: 
Date proposal received: 
Friday, 21 May, 2021
Date proposal approved: 
Tuesday, 1 June, 2021