B3776 - Association of diet and physical activity with serum metabolites and cardiovascular disease risk in adolescents from the ALSPAC - 13/05/2021

B number: 
B3776
Principal applicant name: 
Laura Johnson | University of Bristol (United Kingdom)
Co-applicants: 
Mr Eduard Martinez
Title of project: 
Association of diet and physical activity with serum metabolites and cardiovascular disease risk in adolescents from the ALSPAC
Proposal summary: 

In this study I am going to look at how different lifestyle factors, like foods eaten, timing or frequency of eating, physical activity, sedentary behaviours and their timing or location, combine together to create an overall behavioural pattern score that indicates whether adolescents have good health. It has been previously found that a combination of factors is more important for health compared with single factors alone. I also plan to use a new, reproducible laboratory technique, known as metabolomics, to record over 220 measures of blood that indicate a range of metabolic processes. This will help to find out in much more detail than ever before how behaviour leads to better cardiovascular health via metabolic pathways. When it is known more about the pathway that leads from lifestyle to disease it will be easier to predict who will stay healthy and who will not from their behaviours.

I will be using information from diet diaries, activity monitors and blood samples that have already been provided by Children of the 90s participants when they were teenagers.

Impact of research: 
Identifying the metabolic intermediates between poor health behaviours and long-term metabolic risk has the potential to offer objective methods for monitoring health, looking at responses to intervention and preventing long-term risk of cardiometabolic disease.
Date proposal received: 
Thursday, 13 May, 2021
Date proposal approved: 
Thursday, 13 May, 2021
Keywords: 
Epidemiology, Diabetes, Hypertension, Obesity, Metabolomics, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Sex differences, Blood pressure, BMI, Cardiovascular, Cohort studies - attrition, bias, participant engagement, ethics, Metabolic - metabolism, Nutrition - breast feeding, diet, Physical - activity, fitness, function, Puberty