B3717 - European resource for research into the early life origins of asthma allergy and eczema across the life course EU Child Cohor - 17/02/2021

B number: 
Principal applicant name: 
Liesbeth Duijts | The Generation R Study Group (the Netherlands)
Annemiek Mian, MSc
Title of project: 
European resource for research into the early life origins of asthma, allergy, and eczema across the life course. EU Child Cohor
Proposal summary: 

Since 2003, novel birth cohorts arose and prevalences of asthma, allergy and eczema have not been studied. Combining these data might lead to better understanding of a.o. the impact of these conditions. The aim of our project is to describe the harmonization process of asthma, allergy, and eczema, and relevant related data. We will perform a meta-analysis using individual participant data of cohorts participating in the EU Child Cohort Network and describe the prevalences of wheezing, asthma, upper and lower respiratory tract infections, lung function values, inhalant allergy, inhalant allergic sensitization, food allergy, food allergic sensitization, itchy rash and eczema measured at each age from birth until adolescence while taking country of cohort and main subject characteristics into account. Additionally,we provide a framework for further research into early life stressors, genetic, epigenetic, and microbiome pathways on the risk of developing respiratory and related outcomes.

Impact of research: 
Very high impact, because since 2003 no new prevalence data of respiratory and allergy outcomes have been published, while combining data from different cohorts.
Date proposal received: 
Wednesday, 10 February, 2021
Date proposal approved: 
Thursday, 11 February, 2021
Epidemiology, Allergy, Eczema, Respiratory - asthma, Statistical methods, Cohort studies - attrition, bias, participant engagement, ethics, Childhood - childcare, childhood adversity, Environment - enviromental exposure, pollution, Growth, Sex differences