B3719 - Maternal asthma and offspring methylation EWAS Meta-analysis of PACE cohorts - 16/02/2021

B number: 
B3719
Principal applicant name: 
Raquel Granell | University of Bristol
Co-applicants: 
Klaus B√łnnelykke, Professor, Hanna Elliott, Dr
Title of project: 
Maternal asthma and offspring methylation: EWAS Meta-analysis of PACE cohorts
Proposal summary: 

Background
Asthma is a highly heritable disease with parental asthma being the strongest known risk factor for asthma in the offspring. Maternal asthma is a stronger risk factor than paternal asthma suggesting a role of epigenetic effects. Furthermore, clinical studies have suggested that parental effects might be sex-specific.

Impact of research: 
Date proposal received: 
Monday, 15 February, 2021
Date proposal approved: 
Tuesday, 16 February, 2021
Keywords: 
Genetics, EWAS, Epigenetics