B3705 - Predictors for biological age and age-associated diseases - 25/01/2021

B number: 
Principal applicant name: 
Jennifer Harris | Norwegian Institute of public health (Norge)
Øyvind Helgeland, PhD, Håkon Bøås, Astanand Jugessur, Arne Vasli Lund Søraas, MD, PhD, Espen Riskedal, MSc, Karl Trygve Kalleberg, MD, PhD, Cathrine Lund Hadley, MD, PhD
Title of project: 
Predictors for biological age and age-associated diseases
Proposal summary: 

We want to better understand why some people develop certain disease as they age, while others don’t. We think that by looking at how our genes change their behavior as the body grows older, we can gain new insights into how the aging process leads to disease, and into the aging process itself. This is not only relevant to the typical diseases of the elderly (e.g. rheumatoid arthritis, heart disease, diabetes, dementia and cancer), but also to younger people who develop diseases that are occur at specific age intervals (e.g. MS, infertility, certain cancers).
The project will perform advanced mathematical analyses of the regulation of genes, to develop new computer methods that can predict and explain the development of disease. Our goal is to eventually make new diagnostics, such as blood tests, that can be used to catch age-related diseases earlier and more accurately, so that patients will receive earlier and better treatment.

Impact of research: 
Better and earlier diagnosis of rheumatoid arthritis
Date proposal received: 
Sunday, 24 January, 2021
Date proposal approved: 
Monday, 25 January, 2021
Epigenomics, Bone disorders - arthritis, osteoporosis, Cancer, Cognitive impairment, Fertility/infertility, Hypertension, Infection, Computer simulations/modelling/algorithms, DNA sequencing, Statistical methods, Ageing, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Bones (and joints), Epigenetics