B3688 - Mapping Neurodevelopmental Trajectories for Adult Psychiatric Disorder A focus on Autism and Psychosis - 20/01/2021
B number:
B3688
Principal applicant name:
Anthony David | UCL
Co-applicants:
Miss Sarah Ashley
Title of project:
Mapping Neurodevelopmental Trajectories for Adult Psychiatric Disorder: A focus on Autism and Psychosis
Proposal summary:
This project will investigate neurodevelopmental trajectories for psychiatric disorders, in particular autism and subclinical autistic traits and their overlap with psychosis and psychotic experiences, using longitudinally acquired MRI data from the ALSPAC-MRI-I + II datasets. Analyses will explore the influence of environmental (perinatal and postnatal) and genetic exposures on behaviour. Multi-modal brain imaging scans will be used to illuminate possible interactions between the brain, behaviour, genetics and environmental exposures.
Impact of research:
This research may impact the scientific field by enhancing our understanding of behavioural and biological pathology associated with autism and the potential links to other psychiatric conditions such as psychosis. This research may encourage further research into biomarkers and interventions for autism and overlapping conditions. This work may also inform clinicians and the general public about the presence of autism-related traits in subclinical populations.
Date proposal received:
Friday, 18 December, 2020
Date proposal approved:
Tuesday, 12 January, 2021
Keywords:
Mental health - Psychology, Psychiatry, Cognition, Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Developmental disorders - autism, Mental health, Medical imaging, Statistical methods, Birth outcomes, Development, Equipment - MRI, Environment - enviromental exposure, pollution, Epigenetics, Genetics