B3692 - Pregnancy complications menopausal symptoms and cardiovascular health - 06/01/2021

B number: 
Principal applicant name: 
Abigail Fraser | MRC IEU (United Kingdom)
Title of project: 
Pregnancy complications, menopausal symptoms and cardiovascular health
Proposal summary: 

The link between women's reproductive and cardiovascular health is increasingly recognised. Some, but not all studies have shown that women who experience night sweats and/or hot flushes as part of the menopausal transition are more likely to have heart disease. We also know that women who have complications during pregnancy are at greater risk of heart disease later in life. Here we would like to investigate the associations between all of pregnancy complications, menopausal symptoms and cardiovascular health in a general population of women, the ALSPAC mothers. We will also use genetics data to examine whether genetic risk for for more adverse cardiovascular health are associated with pregnancy complications and/or vasomotor symptoms.

Impact of research: 
This study will improve our understanding of the nature of the relationship between pregnancy complications, VMMS and women's cardiovascular health.
Date proposal received: 
Tuesday, 22 December, 2020
Date proposal approved: 
Wednesday, 6 January, 2021
Epidemiology, DNA sequencing, Statistical methods, Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., BMI, Cardiovascular, Genetic epidemiology, Mothers - maternal age, menopause, obstetrics