B3689 - An individual participant data meta-analysis examining the associations between mode of delivery and respiratory outcomes - 06/01/2021
B number:
B3689
Principal applicant name:
Theodosia Salika | MRC LEU, University of Southampton (United Kingdom)
Co-applicants:
Professor Hazel Inskip
Title of project:
An individual participant data meta-analysis examining the associations between mode of delivery and respiratory outcomes.
Proposal summary:
Systematic reviews and meta-analyses using aggregate data have indicated an increased risk of childhood asthma for women undergoing caesarean section, but the results were subject to moderate heterogeneity, potential residual confounding and publication bias1-4. We aim to use the EU child cohort network to re-examine the associations with different types of delivery using IPD MA to produce a more reliable pooled meta-analytic estimate. Potential mediators such as respiratory tract infections and allergic sensitization will be examined for the associations between different types of mode of delivery and asthma.
Impact of research:
This will provide information about the association between mode of delivery and childhood asthma to inform policy about caesarean section usage.
Date proposal received:
Friday, 18 December, 2020
Date proposal approved:
Wednesday, 6 January, 2021
Keywords:
Epidemiology, Respiratory - asthma, Statistical methods, Cohort studies - attrition, bias, participant engagement, ethics