Cancer outcomes are improved when it is detected early. There is therefore a need for assays for identifying individuals with high cancer risk that can be applied to peripheral tissues such as blood or saliva. There is strong evidence that DNA methylation levels in these tisues encodes biomarkers for cancer risk factors such as cigarette smoke exposure, BMI, diabetes and biological aging. We plan to create DNA methyhlation models of cancer risk factors that can be combined to identify individuals with high cancer risk using peripheral blood samples.