B3652 - Genetics Adverse Childhood Experiences ACEs and Developmental and Behavioral Outcomes - 18/11/2020

B number: 
Principal applicant name: 
Hexuan Liu | University of Cincinnati (United States)
Dr. J.C. Barnes, Dr. Joseph Nedelec, Breanna Clark
Title of project: 
Genetics, Adverse Childhood Experiences (ACEs), and Developmental and Behavioral Outcomes
Proposal summary: 

While previous research has consistently shown a relationship between adverse childhood experiences (ACEs) and developmental and behavioral outcomes later in life, understanding of mechanisms that explain the relationship is still insufficient. In particular, the role of genetics remains unknown. In this project, we propose to study how genetic factors and ACEs jointly and interactively affect individuals' developmental and behavioral outcomes, such as delinquent behavior and substance use. Specifically, we propose to examine whether and to what extent the influence of ACEs on the developmental and behavioral outcomes depends on children’s genetic susceptibility. Moreover, to what extent effects of parental genetic risk on child’s developmental and behavioral outcomes operate via ACEs.

Impact of research: 
The impact of this research will be three-folded. First, it improves our understanding of the role of genetics in research of ACEs on children’s developmental and behavioral outcomes. Second, it highlights the importance of childhood environment on children’s developmental trajectory. Finally, it provides insights to studies of intergenerational influences.
Date proposal received: 
Friday, 13 November, 2020
Date proposal approved: 
Wednesday, 18 November, 2020
Social Science, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., GWAS, Childhood - childcare, childhood adversity, Development, Genomics, Genome wide association study, Offspring, Parenting