B3625 - Green Spaces and Multiple Child Health Outcomes - 02/11/2020

B number: 
Principal applicant name: 
Amanda Fernandes | ISGLOBAL (Spain)
Serena Fossati, Mark Nieuwenhuijsen, Martine Vrijheid
Title of project: 
Green Spaces and Multiple Child Health Outcomes
Proposal summary: 

Early-life urban stressors have been identified as a risk to the onset of non-communicable diseases. An accumulating body of evidence is suggestive for health-promoting effects of exposure to green spaces. However, the association between green spaces and harmful or beneficial effects on children health is still poor for most outcomes, and the underlying mechanisms remain unclear. Outcome wide analysis have recently been proposed as a way to evaluate the effects of exposures over numerous important outcomes. Indeed, some exposures may be harmful for some outcomes and beneficial for others, including green spaces exposures. This approach also has the advantage to better control for confounding for the effects of the exposure on all outcomes simultaneously. It is different from the traditional one-outcome approach and more similar to GWAS (genome wide associations) or EWAS (epigenome wide associations) or ExWAS (exposome wide associations). For outcome-wide approaches, larger datasets are needed so LifeCycle is a good opportunity to apply this novel method. The idea is to add as many outcomes as possible, this is the great interest of the outcome wide approach.

Impact of research: 
Date proposal received: 
Friday, 30 October, 2020
Date proposal approved: 
Monday, 2 November, 2020
Epidemiology, Allergy, Cognitive impairment, Obesity, Statistical methods, Childhood - childcare, childhood adversity