B3640 - Investigating genetic influences on ASD autistic traits and trajectories of autistic traits - 27/10/2020

B number: 
Principal applicant name: 
Zoe Reed | University of Bristol (UK)
Professor Marcus Munafò, Professor Geoge Davey Smith
Title of project: 
Investigating genetic influences on ASD, autistic traits and trajectories of autistic traits
Proposal summary: 

Previous research has shown that autism spectrum disorder is caused by a combination of both genetic and environmental factors. Although studies have identified genes that associated with having ASD, the specific pathways involved in the development and progression of ASD is not well understood. In addition, less is known about the genetic contributions to autistic traits in the more general population and also on the progression of these autistic traits. In this project we would like to address this important gap in our knowledge by investigating these genetic contributions in more detail and by attempting to identify the specific biological pathways that lead to the development of ASD, autistic traits and the progression of these traits over time. To do this we will use data from several cohorts, including Children of the Nineties. The results from this study may inform population health and may help develop more targeted interventions for individuals with ASD symptoms.

Impact of research: 
This research will lead to a better understanding of the genetic influences on autistic trait trajectories which will be useful to compare to those for ASD and autistic traits. Results from our analyses may inform future population health policies and interventions targeted at those with symptoms of ASD.
Date proposal received: 
Friday, 23 October, 2020
Date proposal approved: 
Tuesday, 27 October, 2020
Epidemiology, Developmental disorders - autism, GWAS, Statistical methods, Genetic epidemiology, Genetics, Genome wide association study, Mendelian randomisation, Statistical methods