B3575 - Socioeconomic disparity placental pathology and child development - 07/10/2020

B number: 
Principal applicant name: 
Alexa Freedman | Northwestern University (United States)
Dr. Gregory Miller, Dr. Linda Ernst, Dr. Ann Borders, Dr. Lauren Keenan-Devlin, Dr. Andrew Franklin
Title of project: 
Socioeconomic disparity, placental pathology, and child development
Proposal summary: 

Socioeconomic disadvantage and stress are associated with adverse pregnancy and child health outcomes. There is some evidence to suggest that these associations may be mediated by changes in placental development and function. However, studies of the placenta are often small or limited to pathologic samples, which may not be representative. ALSPAC routinely collected placentas of participants, including term deliveries, and ALSPAC has rich parental sociodemographic information and longitudinal follow-up on child health and development. This presents a unique opportunity to estimate associations between socioeconomic disadvantage and child development and to examine the mediating role of placental pathology in a well-characterized, representative sample.

Impact of research: 
A better understanding of associations between socioeconomic disadvantage, placental pathology and child development may be helpful in identifying the underlying biologic mechanisms. Associations between placental pathology and measures of child health and development may also help to improve early identification of children who may benefit from intervention services or increased monitoring.
Date proposal received: 
Monday, 20 July, 2020
Date proposal approved: 
Tuesday, 21 July, 2020
Epidemiology, Cognitive impairment, Respiratory - asthma, Speech/language problem, Statistical methods, Cardiovascular, Cognition - cognitive function, Development, Speech and language