B3594 - Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia Onset - 14/08/2020
B number:
B3594
Principal applicant name:
Alex Kwong | UoB IEU
Co-applicants:
Professor Nic Timpson, Dr Gail Davies, Professor Ian Deary
Title of project:
Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia Onset
Proposal summary:
This project will provide the most comprehensive interrogation of the genetics of aging-related cognitive changes during prodromal, so-called âsilent,â periods of ADRD progression. Identifying the genetic risk factors and mediating biological mechanisms underlying progression to Alzheimerâs disease and related dementias of aging is crucial to developing interventions to prevent, delay, or otherwise mitigate ADRD disease progression.
Impact of research:
Greater understanding of the genetics underpinning cognitive decline.
Date proposal received:
Wednesday, 12 August, 2020
Date proposal approved:
Friday, 14 August, 2020
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Cognitive impairment, GWAS, Ageing