B3543 - COVID-19- Pregnancy Cardiometabolic health and selection bias - 13/07/2020

B number: 
Principal applicant name: 
Deborah Lawlor | MRC IEU (United Kingdom)
Prof Kate Tilling, Kate Northstone, Gemma Clayton, Ahmed Elhakeem, Dan Smith, Nic Timpson, Simon Haworth, Carolina Borges, Alba Fernandez Sanles
Title of project: 
COVID-19- Pregnancy, Cardiometabolic health and selection bias
Proposal summary: 

We plan to use Children of the 90s to understand the following: (i) whether being smoking, overweight or obese, having higher blood pressure or blood glucose (sugar) or lipids (fat) makes you more likely to become infected with the SARS-CoV2 virus and to have more severe symptoms; (ii) whether having the infection makes these cardiovascular risk factors worise; (iii) whether pregnancy complications (hypertensive disorders of pregnancy, gestational diabetes, having a baby who is small or large at birth, delivering a baby early) that are know to relate to a woman's cardiometabolic health are related to risk of COVID-19 in the mother and their offspring; (iv)is there any evidence that the COVID-19 pandemic and its management is influence decisions about delaying plans to get pregnant / have children and what is the infection rate and severity in couples of reproductive age; (v) is there any evidence that pregnancy increases or decreases risk of COVID-19 risk and severity

Impact of research: 
Informing policy, understanding vulnerable groups
Date proposal received: 
Wednesday, 20 May, 2020
Date proposal approved: 
Thursday, 21 May, 2020
Epidemiology, Hypertension, NMR, Infection COVID-19