B3549 - EWAS of Green Spaces - LifeCycle - 24/06/2020

B number: 
Principal applicant name: 
Kimberley Burrows | MRC IEU (United Kingdom)
Dr. Ahmed Elhakeem, Prof. Debbie Lawlor, Mr Andy Boyd, Mr Richard Thomas
Title of project: 
EWAS of Green Spaces - LifeCycle
Proposal summary: 

The urban exposome (built environment, air pollution, road traffic noise, meteorological, natural space and road traffic) affects health outcomes. For instance, associations between increasing green space exposure and increased birth weight and decreased term low birth weight in 32,000 mother-child pairs have been previously reported (Nieuwenhuijsen et al. 2019).
Here we aim to investigate the epigenetic mechanisms that might mediate this association. We will evaluate the relationship between exposure to green spaces during pregnancy and offspring cord blood DNA methylation at over 450,000 methylation sites (CpG sites) across the genome. This project will contribute epigenome-wide association study summary results to a meta-analysis as part of an ongoing large consortium.

Impact of research: 
To contribute to the wider understanding of the effects of the urban exposome on health outcomes; specifically, in how DNA methylation may mediate these effects. Potential results may lead to significant new understanding and possibly have translatable benefits for improving human health. Such benefits would be to determine new pathways influencing disease that could be potential therapeutic targets.
Date proposal received: 
Friday, 29 May, 2020
Date proposal approved: 
Friday, 29 May, 2020
Epidemiology, No direct analysis of diseases as such, we will be exploring the associations of the environment on DNA methylation. , Statistical methods, Birth outcomes, Environment - enviromental exposure, pollution, Epigenetics