B3371 - Nutritional biomarker in adolescence and adulthood and associations with socioeconomic trajectories and cardiometabolic outcomes - 10/06/2020

B number: 
B3371
Principal applicant name: 
Eleanor Winpenny | MRC Epidemiology Unit, University of Cambridge (United Kingdom)
Co-applicants: 
Dr Albert Koulman
Title of project: 
Nutritional biomarker in adolescence and adulthood and associations with socioeconomic trajectories and cardiometabolic outcomes
Proposal summary: 

Poor quality diet is associated with increased risk of heart disease, stroke, type 2 diabetes, many forms of cancer and mental illness. Poor quality diet is the top contributor to mortality globally, and is estimated to cost the NHS £6billion per year.
The period of adolescence to early adulthood (age 13 to 30) is the time when prevalence of overweight and obesity develops most rapidly, making this an important time to understand the contribution of diet to these developing risk factors. Adolescence and early adulthood is a time of rapid personal development, changing lifestyles, and is the time when adult behaviours, including adult dietary patterns, are developed and established. Understanding the factors that influence development of diet is an important first step in developing strategies to change behaviour.
There is limited data available on changes in diet through adolescence and early adulthood in the UK. Self-reported diet data is notoriously biased, however recent advances in biomarker research have established several biomarkers that are reliable indicators of consumption of specific foods and food groups. In this project we will analyse blood samples from the ALSPAC cohort, taken at age 13, 15, 17, 24 and 30, to derive measures of intake of fruit and vegetable, dairy and fish intake.
We will use these measures of diet to assess (1) changes in diet across adolescence and early adulthood, (2) associations between socioeconomic changes in adolescence and early adulthood and changes in diet, (3) the role of changes in diet in pathways linking socioeconomic determinants and risk factors for cardiovascular disease.

Impact of research: 
Collection of this data will allow research which helps us to understand the role of diet within pathways which lead from socioeconomic determinants to cardiovascular and metabolic disease. In particular this research will provide information on the populations at risk for development of poor diet during early adulthood, and suggest opportunities for public health intervention. For example research based on this data could identify particular population groups or particular early adulthood life transitions that increase risk of a poor quality diet, suggesting a particular targets for intervention. In addition, the analysis of nutritional biomarkers across this age range will feed data back into the ALSPAC cohort, for future analysis. This will allow analysis of relationships between diet in adolescence and early adulthood with future measures of health and disease.
Date proposal received: 
Wednesday, 11 September, 2019
Date proposal approved: 
Wednesday, 11 September, 2019
Keywords: 
Epidemiology, Cancer, Diabetes, Hypertension, Obesity, Statistical methods, Nutritional biomarker analysis - high-performance liquid chromatography and lipidomics, Biological samples -e.g. blood, cell lines, saliva, etc., Biomarkers - e.g. cotinine, fatty acids, haemoglobin, etc., Blood pressure, BMI, Cardiovascular, Metabolic - metabolism, Nutrition - breast feeding, diet, Social science