B3523 - Fine-mapping of vascular reactivity loci using human artery multi-omics analyses - 01/05/2020

B number: 
Principal applicant name: 
Clint Miller | University of Virginia (USA)
Title of project: 
Fine-mapping of vascular reactivity loci using human artery multi-omics analyses
Proposal summary: 

Vascular diseases such as hypertension, migraine, and atherosclerosis (hardening of arteries) involve changes in vascular cell function with reduced ability to contract and relax in response to different stresses. This results in chronic alterations in artery blood flow and maladaptive structural changes to the vascular wall leading to injury, tissue damage, and increased risk for life-threatening diseases such as stroke and heart attacks. Given that naturally occurring genetic variation contributes to changes in vascular function along with environmental risk from early life stages, it is now critical to evaluate the effects of these genetic associations at this stage using more systematic approaches. We plan to integrate these vascular phenotype data with high resolution molecular data to better understand how these genetic risk factors impact vascular disease risk at an early age.

Impact of research: 
The results of these analyses will lead to high impact publications and valuable summary datasets to enable the development of novel diagnostic, prognostic and therapeutic strategies to mitigate a range of debilitating vascular diseases.
Date proposal received: 
Tuesday, 28 April, 2020
Date proposal approved: 
Friday, 1 May, 2020
Genetics, Endothelial dysfunction/artery stiffness (subclinical vascular disease) , Computer simulations/modelling/algorithms, DNA sequencing, Gene mapping, GWAS, Genetic epidemiology, Genetics, Genomics