B3479 - The determinants and burden of gastrointestinal infection a tale of two generations - 10/03/2020

B number: 
B3479
Principal applicant name: 
Mara Violato | Health Economics Research Centre, University of Oxford (United Kingdom)
Co-applicants: 
Dr Daniel Hungerford, Professor Miren Iturriza-Gomara, Professor Noel McCarthy, Professor Benjamin Barr
Title of project: 
The determinants and burden of gastrointestinal infection: a tale of two generations?
Proposal summary: 

Gastrointestinal infections are common, with 1 in 4 people in the UK population experiencing an episode each year, which causes an estimated annual cost to the individuals, the National Health Service and the wider economy of £1.5 billion. This research will take a life-course approach to the assessment of the causes and consequences of gastrointestinal infections in the community, from early childhood into early adulthood – continuing into the next generation (ALSPAC-G2 study: Children of the Children of the 90s). This will allow us to provide important insights into changes in causes and consequences of gastrointestinal infections across the individual life-course but also over time at the population level. The findings can then inform public health interventions to reduce the burden of gastrointestinal infections, especially among the most vulnerable groups.

Impact of research: 
Greater understanding of risk factors for and the burden of gastrointestinal infections in the community across the individual life-course but also over time at the population level. The first evaluation of the impact of paediatric rotavirus vaccination on mild community diarrhoea in the UK. Guidance for developing community based/led gastrointestinal infection surveillance platforms.
Date proposal received: 
Friday, 6 March, 2020
Date proposal approved: 
Saturday, 7 March, 2020
Keywords: 
Health Economics, Gastrointestinal, Statistical methods, Health economics, life-course approach, infections