B3462 - INFLUENCE OF EARLY-LIFE PET EXPOSURES ON THE RISK OF ALLERGIC SENSITISATION AND ASTHMA IN CHILDHOOD - 03/03/2020

B number: 
B3462
Principal applicant name: 
Angela Pinot de Moira | University of Copenhagen (Denmark )
Co-applicants: 
Title of project: 
INFLUENCE OF EARLY-LIFE PET EXPOSURES ON THE RISK OF ALLERGIC SENSITISATION AND ASTHMA IN CHILDHOOD
Proposal summary: 

Studies investigating the influence of early-life pet exposures on the risk of childhood asthma have been inconsistent: some studies have observed a decreased risk whilst others have observed no effect or even an increased risk of asthma following early-life pet exposure. This study aims to use data from several longitudinal studies to investigate how exposure to pets during pregnancy or early-life influences the likelihood of: a) the immune system recognising allergens (allergic sensitisation); b) developing asthma. The study will also investigated the relative influence of type (dogs vs. cats), timing (pregnancy, early life, never) and degree (number) of pet exposures on allergic sensitisation and asthma.

Impact of research: 
Results will further our understanding of the aetiology of asthma, highlight possible intervention strategies to reduce asthma incidence and severity, and help create more  effective guidelines regarding animal exposures during pregnancy and early-life
Date proposal received: 
Tuesday, 4 February, 2020
Date proposal approved: 
Wednesday, 5 February, 2020
Keywords: 
Epidemiology, Respiratory - asthma, Statistical methods, Pets