B3473 - Metabolomic quality control and association analyses - 24/02/2020

B number: 
Principal applicant name: 
Nicholas Timpson | MRC IEU (United Kingdom)
Mr Matthew Lee, Dr Laura Corbin, Dr David Hughes, Dr Kaitlin Wade
Title of project: 
Metabolomic quality control and association analyses
Proposal summary: 

Metabolites are the ultimate end-point of a biological process and are therefore seen as a link between genotype and phenotype. Assigning individual metabolite changes to diseases is difficult because of the complexity of their interrelationships. Prior to analysis quality control of metabolomics data is required. We have developed a package that automates these quality control steps. We will use the raw metabolomic data as a use case for our package.

Body composition is known to affect metabolite concentrations. These changes may be implicated in disease development. Following quality control we will use the metabolomic data to investigate the relationship between metabolites and different body composition traits.

Impact of research: 
Evaluation of metabolite quality control package. Greater understanding of the relationship between metabolites and body composition.
Date proposal received: 
Monday, 24 February, 2020
Date proposal approved: 
Monday, 24 February, 2020
Epidemiology, Obesity, Metabolomics, Statistical methods, BMI, Genetics, Mendelian randomisation, metabolomics