B3455 - Cardiorespiratory fitness adiposity and lean mass in relation to arterial structure and function from childhood to adulthood - 03/02/2020

B number: 
Principal applicant name: 
Prof. Tomi-Pekka Tuomainen | University of Eastern Finland (Finland)
Dr. Andrew O. Agbaje, Dr. Alan R. Barker
Title of project: 
Cardiorespiratory fitness, adiposity, and lean mass in relation to arterial structure and function from childhood to adulthood
Proposal summary: 

Cardiovascular disease, a frontline cause of death worldwide, has some risk factors such as obesity, poor cardiorespiratory fitness (CRF), and vascular dysfunction whose primordial signs exist in childhood. Evidence suggests that excess body fat and poor CRF predict increased cardiometabolic risk and the progression of atherosclerosis. However, the mechanisms underlying vascular dysfunction with respect to predictors such as CRF, body fat, and lean mass in the young remains poorly understood.

It is unclear whether CRF in childhood and adolescence impact arterial structure and function in later life. Although several studies have assessed the influence of childhood CRF on early and or later arterial health, they are either of cross-sectional or short-term longitudinal design. Most of these studies have focused on a specific period (e.g. early or late childhood) and are restricted to a one-time measure of CRF. Moreover, inappropriate scaling measure of CRF such as not accounting for the confounding effect of body fat makes interpretation of existing evidence difficult.

Similarly, accumulation of body fat and lean mass during childhood through adolescence may significantly impact arterial health in early adulthood. But, studies that describe the physiological adaptation of vascular structure through adolescence to young adulthood in relation to increased body fat and lean mass are few. A repeated measure of CRF, body fat and lean mass is essential to determining critical periods of early life during which these factors implicate later arterial health. Evidence on suitable target ages for cardiovascular intervention, alongside unraveling the cryptic mechanisms by which CRF, body fat and lean mass relate to arterial health could be achieved. We would, therefore, assess the importance of early life exposures (e.g. CRF, body fat, lean mass, and/or endothelial function) from childhood through adolescence on vascular phenotypes between ages 9 to 24.

Impact of research: 
We aim to publish our findings in international peer-reviewed journals and also disseminate press releases to the general public via news channels. To provide scientific evidence on possible age-specific interventions that could mitigate the sub-clinical progress of arterial diseases from childhood.
Date proposal received: 
Thursday, 30 January, 2020
Date proposal approved: 
Monday, 3 February, 2020
Paediatric Exercise Medicine/Physiology and Epidemiology, Hypertension, Obesity, Atherosclerosis, myocardial infarction, cardiovascular disease, metabolic disorders, Statistical methods, Allometric scaling, mixed-method, Biological samples -e.g. blood, cell lines, saliva, etc., Blood pressure, BMI, Cardiovascular, Cohort studies - attrition, bias, participant engagement, ethics, Childhood - childcare, childhood adversity, Physical - activity, fitness, function, Puberty, Sex differences, Statistical methods, Cardiorespiratory fitness, endothelial function, metabolic health, carotid intima-media thickness, arterial distensibility, obesity, fat-free mass, fat mass, cardiovascular health, arterial stiffness, childhood, adolescence, early adulthood, atherosclerosis, cardiovascular diseases, public health.