Few studies have examined a large number of placenta from general population samples. There are therefore many unanswered questions about the links between placental abnormalities and maternal and offspring health in pregnancy and beyond. ALSPAC is unique, with some 10000 stored placentas from the original ALSPAC pregnancies in the early 90s. We will generate pathology data on this collection and study placental findings in relations to short term health in mums and their offspring.