B3442 - The biological background of attention-deficit/hyperactivity disorder - 14/01/2020
B number:
B3442
Principal applicant name:
Hannah Sallis | MRC IEU
Co-applicants:
Ville Karhunen, Gemma Sharp, Marcus Munafo, Claire Prince, Marjo-Riitta Järvelin
Title of project:
The biological background of attention-deficit/hyperactivity disorder
Proposal summary:
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by persistent patterns of inattention, hyperactivity and/or impulsivity, which interfere with normal functioning or development. ADHD is highly heritable, with heritability estimates from twin studies at around 75%. It is also suggested that epigenetic modifications â alterations in the DNA not changing the sequence itself â play a role in ADHD aetiology. In addition, there is known shared genetic liability between obesity and ADHD. Maternal obesity is a known risk indicator for offspring ADHD, however it is not clear whether this is due to the shared genetic predisposition, or possible intrauterine mechanisms.
Impact of research:
Adding information to the biological background of attention-deficit/hyperactivity disorder.
Date proposal received:
Monday, 13 January, 2020
Date proposal approved:
Tuesday, 14 January, 2020
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Developmental disorders - autism, Mental health, Statistical methods, Cohort studies - attrition, bias, participant engagement, ethics, Childhood - childcare, childhood adversity, Epigenetics, Genetic epidemiology, Statistical methods