B3338 - Psychiatric outcomes of sexual assault - 07/08/2019

B number: 
B3338
Principal applicant name: 
Laura Huckins | Icahn School of Medicine at Mount Sinai (USA)
Co-applicants: 
Hillary Duenas, Hannah Young, Alanna Cote, Lora Liharska, Jessica Johnson, Dannielle Lebovitch, Lauren Blake, Eli Stahl, Alex Charney, Niahm Mullins
Title of project: 
Psychiatric outcomes of sexual assault
Proposal summary: 

Sexual assault (SA) is a key risk factor for the development of post-traumatic stress disorder (PTSD) and other psychiatric disorders. However, despite the ubiquity of sexual assault, many individuals do not develop any PTSD or other psychiatric disorders. Predicting which individuals may be at higher risk of PTSD, and identifying clinical and biological factors that lead to resilience or disease risk will be vital to developing new treatments and therapies, and in matching patients to appropriate, timely interventions. We propose to use environmental, genetic and methylation data from the ALSPAC cohort, to identify the key factors influencing psychiatric disease risk and resilience after sexual assault.

Impact of research: 
First and foremost, our research highlights the importance of understanding and ending sexual assault. Our existing studies already demonstrate the outsized role that sexual assault has in shaping the lives and experience of survivors; however, the ubiquity of sexual assault, and the huge role of sexual assault in PTSD development, is not yet appreciated. We hope that our work will highlight this. Second, we describe a simple and useful model to study resilience to trauma. PTSD studies to date have focused on the severity of PTSD, or case-control status, without taking trauma into account. Our model may be easily applied to a range of trauma types and cohorts. Third, by identifying genetic, epigenetic, and environmental predictors of resilience, we hope to understand the biological mechanisms of PTSD and wellness. Identifying these mechanisms and pathways will allow us to improve care for survivors, and hopefully to develop new therapeutics and interventions.
Date proposal received: 
Friday, 28 June, 2019
Date proposal approved: 
Monday, 1 July, 2019
Keywords: 
Genetics, Addiction - e.g. alcohol, illicit drugs, smoking, gambling, etc., Behaviour - e.g. antisocial behaviour, risk behaviour, etc., Developmental disorders - autism, Cognitive impairment, Eating disorders - anorexia, bulimia, Learning difficulty, Mental health, Obesity, Sexually transmitted diseases, chlamydia, gonorrhoea, Sexual assault Psychiatric traits / diseases Domestic Violence Child Abuse, Computer simulations/modelling/algorithms, GWAS, RNA, Statistical methods, Environment - enviromental exposure, pollution, Genetics, Genomics, Genome wide association study, Psychology - personality, Statistical methods