B3323 - Longitudinal genome-wide association study of bone accrual in ALSPAC - 03/06/2019

B number: 
B3323
Principal applicant name: 
Ahmed Elhakeem | MRC Integrative Epidemiology Unit at University of Bristol
Co-applicants: 
Diana Cousminer
Title of project: 
Longitudinal genome-wide association study of bone accrual in ALSPAC
Proposal summary: 

While many genetic loci are known to be associated with adult areal bone mineral density (aBMD), less is known about genetic determinants of bone accrual. Our aims is to replicate in ALSPAC novel genome-wide associations with bone accrual in the Bone Mineral Density in Childhood Study.

Impact of research: 
High value publication
Date proposal received: 
Monday, 3 June, 2019
Date proposal approved: 
Monday, 3 June, 2019
Keywords: 
Genetic epidemiology (including association studies and mendelian randomisation), GWAS, Statistical methods, Growth, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc.