B3318 - Genetics of Child Growth Trajectories - 23/05/2019
B number:
B3318
Principal applicant name:
Kateryna D. Makova | Penn State University Department of Biology (United States)
Co-applicants:
Sarah JC Craig, PhD, Francesca Chiaromonte, PhD, Matthew L. Reimherr, PhD, Ana Kenney
Title of project:
Genetics of Child Growth Trajectories
Proposal summary:
Our team is interested in variables that influence the weight gain patterns of young children. In this study we aim at identifying genetic variants (differences in the DNA between individuals) that could be used to predict which children are most at risk at developing childhood obesity. With this information we could identify children who would benefit most from early life obesity interventions.
Impact of research:
Childhood obesity is a growing epidemic. With early life interventions, this growth could be prevented or even reversed. However, these interventions can often be expensive and labor intensive, which precludes their widespread implementation. If a test (such as a PRS) could be performed that identifies children who are most at risk of developing childhood obesity, intervention efforts could be focused on that sub-population. This would decrease the burden of intensive intervention programs.
Date proposal received:
Tuesday, 21 May, 2019
Date proposal approved:
Thursday, 23 May, 2019
Keywords:
Genetic epidemiology (including association studies and mendelian randomisation), Obesity, GWAS, Statistical methods, Birth outcomes, BMI, Childhood - childcare, childhood adversity, Genetic epidemiology, Genetics, Genomics, Growth, Methods - e.g. cross cohort analysis, data mining, mendelian randomisation, etc., Statistical methods